A Beginner's Guide To Alprostadil Cream And Injections For Erectile Dysfunction

Alprostadil is a well-established and effective treatment for erectile dysfunction (ED), offering an alternative to traditional oral medications. With its unique mechanism of action, it helps improve blood flow to the penis, enabling men to achieve and maintain an erection. Available in two main forms—cream and injections—Alprostadil provides a reliable option for those who may not respond to or are unable to take oral ED treatments. This article will explore how Alprostadil works, when it might be prescribed, and how to use it safely and effectively.

Key Takeaways

What is Alprostadil?

Alprostadil is a treatment for erectile dysfunction (ED) that improves blood flow to the penis, helping men achieve and maintain an erection. It comes in three forms: cream, injections, and urethral suppositories, offering options for those who cannot use oral medications like sildenafil or tadalafil.

How Alprostadil Works

Alprostadil mimics a natural substance in the body (PGE1) to relax blood vessels and increase blood flow to the penis. Creams take 5-30 minutes to work, while injections act faster, within 5-20 minutes. The effects usually last 1-2 hours.

When and How to Use Alprostadil

Alprostadil is typically prescribed when other ED treatments fail or aren’t suitable. You need a prescription to purchase it, which can be obtained online through UK Meds after a free consultation. Always follow your doctor’s guidance to use it safely and effectively.

How is Alprostadil used to treat erectile dysfunction?

Alprostadil works by increasing blood flow to the penis, which helps men with ED achieve an erection. There are two main forms of Alprostadil: cream and injections.

• Alprostadil cream, also known as topical Alprostadil, is applied directly to the tip of the penis. It is absorbed through the skin and works by relaxing the blood vessels, which allows more blood to flow to the penis, promoting an erection.

• Alprostadil injections involve injecting the medication into the base or side of the penis using a fine needle. This method also increases blood flow, helping men to get a firm and lasting erection.

Both methods are effective for many men, with the injection option often providing a faster response.

Is Alprostadil a First-Choice Treatment for ED?

While Alprostadil is a highly effective treatment, it is typically not a first-choice treatment for erectile dysfunction. Oral medications like sildenafil (Viagra) or tadalafil (Cialis) are often the first options prescribed by healthcare professionals. Alprostadil is usually recommended when oral medications have proven ineffective or are not suitable due to other health conditions.

For some men, Alprostadil may be used as a second-line treatment, particularly if oral medications are not an option or have not provided satisfactory results. Alprostadil can also be a suitable option for individuals with certain medical conditions that affect the ability to achieve or maintain an erection.

When is Alprostadil Prescribed?

Healthcare professionals may prescribe Alprostadil in the following circumstances:

• Failure of oral medications: If ED medications like sildenafil or tadalafil do not work, or if they are unsuitable for a patient due to medical conditions, Alprostadil may be considered as an alternative.

• Neurological conditions: Men with conditions like spinal cord injury or multiple sclerosis may be prescribed Alprostadil, as these conditions can affect the ability to achieve an erection.

• Patient preference: Some men may prefer Alprostadil, either because of convenience, or comfort with the method of administration, whether cream or injection.

What is Prostaglandin E1 (PGE1)?

• Alprostadil is a synthetic form of Prostaglandin E1 (PGE1), which is a naturally occurring hormone-like substance in the body. PGE1 plays a crucial role in regulating various physiological processes, including blood flow, inflammation, and smooth muscle relaxation. Alprostadil works by mimicking the effects of PGE1, relaxing the smooth muscles in the penis, dilating the blood vessels, and enhancing blood flow to enable an erection.

PGE1 vs. PDE5 Inhibitors: What’s the Difference?

Both PGE1 and PDE5 inhibitors (such as sildenafil and tadalafil) are used to treat ED, but they work differently:

Common Side Effects of Alprostadil

Like all medications, Alprostadil can cause side effects. The most common side effects include:

• Penile pain or discomfort

• Urethral burning or irritation

• Priapism (prolonged, painful erection)

• Redness or swelling at the injection site or where the cream is applied

• Hypotension (low blood pressure)

Uncommon Side Effects

Less common side effects include:

• Fibrosis (penile curvature or deformity)

• Allergic reactions

• Hypersensitivity (redness, swelling, or itching)

• Urinary tract conditions

While these side effects are rare, it is important to seek medical attention if they occur, especially if you experience prolonged erections lasting over four hours.

Is Alprostadil a Vasodilator?

Yes, Alprostadil is a vasodilator, meaning it works by relaxing and widening blood vessels. This action increases blood flow to the penis, allowing for the development and maintenance of an erection. By improving blood flow, Alprostadil helps men with erectile dysfunction achieve better sexual performance.

How Quickly Does Alprostadil Work?

• Alprostadil cream typically takes effect within 5 to 30 minutes after application.

• Alprostadil injections work more quickly, usually producing results within 5 to 20 minutes.

How Long Does Alprostadil Last?

The effects of both Alprostadil cream and injections usually last for 1 to 2 hours. The duration can vary depending on the individual, but it’s important to follow the dosage instructions carefully to avoid complications, such as a prolonged erection.

How to Use Alprostadil Cream

To use Alprostadil cream effectively:

1. Wash your hands thoroughly with warm water and soap.

2. Apply the cream to the tip of your penis.

3. Massage the cream gently into the head and shaft of the penis.

4. Wait for 5 to 30 minutes before engaging in sexual activity.

Always follow the specific instructions provided by your healthcare provider or in the patient information leaflet.

How to Use Alprostadil Injections

For Alprostadil injections, it's important to:

1. Use a clean needle and injection site.

2. Inject the medication into the base or side of your penis using a fine needle.

3. Follow instructions provided with your medication to ensure safety.

Be sure to consult a healthcare professional before using Alprostadil injections for the first time.

Other Forms of Alprostadil

In addition to cream and injections, Alprostadil is available in a urethral suppository form, which is inserted into the urethra using a special applicator. This alternative method may be preferred by some men who are uncomfortable with injections.

Alprostadil Brand Names

The most common brand name for Alprostadil cream is Vitaros. It’s important to know the different brand names so you can easily identify your medication.

Who Should Avoid Alprostadil?

Alprostadil may not be suitable for everyone. You should avoid Alprostadil if:

• You are allergic to Alprostadil or any other ingredients in the product.

• You have a history of priapism (painful erections).

• You have conditions that increase the risk of bleeding.

• You have a genital infection or inflammation.

• You have been advised to avoid sexual activity for medical reasons.

Always consult with your doctor to determine if Alprostadil is safe for you.

Do I Need a Prescription for Alprostadil?

Yes, you need a prescription to buy Alprostadil cream or injections. If you believe Alprostadil could be a suitable treatment for your erectile dysfunction, it’s important to consult a healthcare professional.

Can I Get a Prescription for Alprostadil Online?

Yes, you can get a prescription for Alprostadil online through UK Meds. By completing a free online consultation, you can receive a private prescription and purchase your medication without having to visit your GP.

Where Can I Buy Alprostadil Online?

You can purchase Alprostadil cream (Vitaros) online through UK Meds. Simply complete our free consultation and have your medication delivered to your door.

Final Thoughts

Alprostadil is a highly effective treatment for erectile dysfunction, offering men an alternative when other options have failed. Whether you opt for the cream, injection, or urethral suppository form, Alprostadil can help improve blood flow and facilitate the ability to achieve and maintain an erection. Always follow your doctor’s instructions and seek advice before starting treatment.

Sources

• Patient.info - Alprostadil for Erectile Dysfunction

• Newcastle Hospitals NHS - Penile Injections for Erectile Dysfunction (Impotence)

• Cambridge University Hospitals NHS - Penile Injections for Impotence

• Prostate Cancer UK Community - Alprostadil Injections and Cream

• Drug and Therapeutics Bulletin - Alprostadil Injections for Erectile Dysfunction

• NICE CKS - Erectile Dysfunction

• NHS - Erection Problems (Erectile Dysfunction)

• BNF - Alprostadil

• NICE - Alprostadil Cream for Erectile Dysfunction (PDF)

• Medicines.org.uk - Alprostadil Summary of Product Characteristics

• Dovepress - Clinical Use of Alprostadil Topical Cream in Patients with Erectile Dysfunction

• East and North Hertfordshire CCG - Alprostadil Cream (Vitaros) for Erectile Dysfunction (PDF)