How Much Weight Can You Lose on Orlistat?

In this article, we’ll explain how Orlistat works to reduce weight, how effective it is and how quickly you can expect to see results. You'll also learn how to get the best outcomes when using it, as well as alternative treatments that are available. If you are struggling with your weight and think you require medication to help you lose weight it is important to consult with your doctor for advice tailored to you and your body. 

Key Takeaways

Here are the 5 biggest takeaways from this article about losing weight with Orlistat:

• Orlistat is a licensed weight loss medication in the UK, available by prescription and in a lower-dose form (Alli) over the counter.

• Orlistat works by blocking enzymes that break down dietary fat, leading to approximately one-third of the fat consumed being excreted rather than absorbed.

• Clinical studies show that Orlistat is effective for weight loss, typically leading to noticeable results within two months.

• To achieve the best results with Orlistat, it is crucial to follow a balanced diet, engage in regular exercise, stay hydrated, get adequate sleep, and manage stress.

Several other weight loss medications are available in the UK, including injectable options like Mounjaro, Wegovy, and Saxenda.

Is Orlistat a licensed weight loss medication in the UK?

Yes, Orlistat is a licensed weight loss medication in the UK. It is available on prescription from reputable online prescription services, including UK Meds (NHS, 2023). There is also a lower-dose version of Orlistat available called Alli. This medication is available to buy over-the-counter but it is advised that you consult with your doctor or a pharmacist before you begin using it to ensure that it is right for you. You can also buy Alli online from UK Meds.

How does Orlistat work to reduce weight?

Orlistat helps reduce weight by preventing your body from absorbing all the fat you consume. It works by blocking the enzymes that break down fat, meaning about a third of the fat from your food is not absorbed and is instead passed through your stools. This reduction in fat absorption helps to lower your overall calorie intake, supporting weight loss when combined with a healthy diet (NHS, 2022).

How effective is Orlistat at reducing weight?

Orlistat has been shown to be effective at promoting weight loss, with noticeable results typically seen after two months of use (Bansal, Patel & Al Khalili, 2024). You will usually need to take an Orlistat tablet after every meal which can be three times a day. In clinical studies, Orlistat has been shown to be effective at reducing body weight when compared to a placebo, with some results showing patients losing twice as much weight when using the medication (Jain et al, 2011).

Orlistat may not lead to dramatic weight loss, however, it can be beneficial for people who need a little bit of extra help with their weight loss efforts (Drew, Dixon & Dixon, 2007). To achieve the best results when using Orlistat it is best to use it alongside a healthy, balanced diet, regular exercise and lifestyle changes (Chanoine, Hampl & Jensen, 2005).

How fast can you lose weight with Orlistat?

When using Orlistat, the goal is often to achieve at least a 5% weight loss within three months. If you do not achieve this target it is unlikely that Orlistat will be effective for you and the treatment should be stopped (Tidy & McKechnie, 2024). The fat digestion effects of Orlistat should begin 1 to 2 days after you start using the medication (NHS, 2023). This should help to provide noticeable weight loss after 3 months.

If you are concerned about the results you are getting when using Orlistat it is important to consult with your doctor for advice. Do not stop using the medication without being told to by your doctor.

How can you get the best results when using Orlistat?

To get the best results when using Orlistat, it's important to follow a few key steps. Firstly it is important to speak with your doctor to ensure the treatment is safe and suitable for you. Your doctor will be able to provide you with tailored advice for your situation.

We have previously provided a number of different tips for losing weight safely and effectively. These tips can be used alongside Orlistat and include:

• Eating a healthy, balanced diet high in fibre and protein

• Reduce fat, sugar and processed food intake

• Get at least 30 minutes of regular exercise

• Stay hydrated

• Aim for 7 to 8 hours of sleep per night

• Manage your stress levels

Are alternate weight loss treatments available?

Yes, there are a number of weight loss medications that are licensed for use in the UK. The most popular weight loss treatments available in recent times are self-injectable medications. Below are three of the most popular weight loss injection pens available to buy from UK Meds:

Mounjaro

Mounjaro is a weight loss injection used by obese people or people with a weight-related health condition. Mounjaro contains the active ingredient tirzepatide, which helps with weight loss by enhancing insulin sensitivity, reducing appetite and promoting a feeling of fullness, leading to reduced calorie intake.

Wegovy

Wegovy is another injectable medication which is used for aiding weight loss for people who are obese or have a weight-related health condition. The active ingredient in Wegovy is semaglutide, which helps with weight loss by mimicking a hormone that targets areas of the brain responsible for regulating appetite, reducing hunger and helping people feel fuller for longer. 

Another injectable medication that contains semaglutide is Ozempic, which is licensed for treating type 2 diabetes and cannot be prescribed for weight loss.

Saxenda

Saxenda is also a weight loss injection used by obese people or people with a weight-related health condition. The active ingredient in Saxenda is liraglutide, which aids weight loss by slowing down digestion and reducing appetite, helping people eat less and manage their weight.

Sources

Orlistat 120 mg capsules - Patient Information Leaflet

Obesity - Treatment - NHS

Orlistat (Weight Loss Medicine): Uses and Side-Effects - Patient