Understanding The Link Between Metformin and Weight Loss

In this article, we’ll explore the connection between metformin and weight loss. We’ll look at whether metformin actually causes weight loss, if it is licensed for weight management in the UK and what alternative weight loss medications are available. As well as this, we will discuss natural methods for losing weight and how these compare to using medications.

Key Takeaways

Here are the 5 biggest takeaways from this article about Metformin and weight loss:

• While metformin may cause weight loss in some people, it is not significant for most, and weight loss is not guaranteed.

• Metformin is not licensed for weight loss in the UK. Its primary use is to manage type 2 diabetes by controlling blood sugar levels.

• Several other medications are licensed for weight loss in the UK, including Wegovy, Mounjaro, Saxenda, and Orlistat.

• For those who do experience weight loss while on metformin, it tends to be safe and sustained over time, especially when the medication is used as prescribed.

• Natural weight loss can be achieved through a healthy, balanced diet, regular exercise, adequate sleep and hydration.

Does Metformin cause weight loss?

Metformin is a medication used to help treat type 2 diabetes. Despite some misconceptions, it does not directly cause weight loss, but some people may experience modest weight reduction while taking it according to the NHS. This weight loss experienced whilst using Metformin is not usually significant, and many people may not experience any at all (Anderson, 2023).

Some people may experience more weight loss than others when they are using Metformin. People with severe insulin resistance for example may experience more noticeable weight loss compared to those who are more insulin-sensitive (Seifarth, Schehler & Schneider, 2012). 

When someone is experiencing weight loss as a side effect of Metformin it is often sustained over the course of using the treatment and is considered to be completely safe. The chances of experiencing this weight loss are also more likely to occur in people using the medication as advised (Yerevanian & Soukas, 2019). This effect is not just noticed in adults as children who have used the medication have also experienced safe, mild weight loss (Yanovski et al, 2011).

Is Metformin licensed for weight loss in the UK?

Metformin is not licensed for weight loss in the UK. It is primarily prescribed to manage type 2 diabetes by helping to control blood sugar levels (Diabetes UK, 2024). Although some individuals may experience weight loss as a side effect, this is not its intended or approved use.

What alternate medications are licensed for weight loss in the UK?

As Metformin is licensed for treating type 2 diabetes, people looking for weight loss medications will need to find alternative options. Thankfully, there are a number of different weight loss medications available in the UK, including:

Wegovy

Wegovy is an injectable medication which is used for aiding weight loss for people who are obese or have a weight-related health condition. The active ingredient in Wegovy is semaglutide, which helps with weight loss by mimicking a hormone that targets areas of the brain responsible for regulating appetite, reducing hunger and helping people feel fuller for longer. 

Another injectable medication that contains semaglutide is Ozempic, which is licensed for treating type 2 diabetes and cannot be prescribed for weight loss.

Mounjaro

Mounjaro is also a weight loss injection used by obese people or people with a weight-related health condition. Mounjaro contains the active ingredient tirzepatide, which helps with weight loss by enhancing insulin sensitivity, reducing appetite and promoting a feeling of fullness, leading to reduced calorie intake.

Saxenda

Saxenda is another weight loss injection used by obese people or people with a weight-related health condition. The active ingredient in Saxenda is liraglutide, which aids weight loss by slowing down digestion and reducing appetite, helping people eat less and manage their weight.

Orlistat

Orlistat is a weight loss medication that comes in the form of capsules. Orlistat works by blocking the absorption of some of the fat from food, helping reduce overall calorie intake

How can I lose weight naturally?

To lose weight naturally, you should eat a healthy, balanced diet that’s high in fibre and protein and low in processed foods, sugar and fats. Regular exercise, at least 30 minutes on most days, along with staying hydrated and getting 7-8 hours of sleep each night, also play key roles in losing weight naturally.

We have previously provided detailed articles on advice on losing weight, and whether losing a stone in a month is possible, which you may find beneficial.

Sources

Common questions about metformin - NHS.

Metformin and diabetes - Diabetes UK

Metformin (Glucophage) and Weight Loss - Diabetes.co.uk