Microdosing GLP-1 Medications for Weight Loss: Is It A Good Idea?

Microdosing GLP-1 medications, such as Mounjaro and Wegovy, has become a trending topic in the world of weight loss. These injections mimic the GLP-1 hormone to help regulate blood sugar and promote feelings of fullness, making them effective for managing weight. But what exactly does “microdosing” mean, and is it a safe and effective strategy for weight loss? In this article, we’ll look into the concept of microdosing these medications, explain the recommended dosages and whether changing them could pose risks, and explore whether this approach could deliver the results people hope for.

Key Takeaways

Here are the 5 biggest takeaways from this article about microdosing GLP-1 medications:

• The concept of microdosing Mounjaro and Wegovy, which involves taking smaller-than-recommended doses, is not supported by clinical evidence.

• These medications are designed to work at specific, clinically tested dosages. Microdosing can lead to underdosing, which reduces the medication's ability to control blood sugar levels and aid weight loss.

• Taking smaller doses does not necessarily reduce the risk of side effects such as nausea, vomiting, diarrhoea and gastrointestinal upset.

• Mounjaro and Wegovy follow dosage titration schedules to maximise their safety and effectiveness. This means your dosage gradually increases over time.

• Adjusting the dosage of GLP-1 medications without medical guidance is not recommended. Changes should always be discussed with a healthcare professional to ensure safety and efficacy.

What is microdosing of Mounjaro and Wegovy?

Microdosing Mounjaro or Wegovy, two very popular GLP-1 weight loss medications, typically involves taking a smaller dose of the medication than the recommended amount. The concept is not endorsed or supported by clinical evidence, however, some people have taken to microdosing for a number of reasons.

Some claims suggest that smaller doses might help achieve weight loss or blood sugar control while potentially reducing side effects. Other people have turned to microdosing to try and save money, stretching the use of a single injection pen or using lower doses to make the medication more affordable over time. Some people also view microdosing as a way to prevent the weight gain that sometimes happens when someone stops using the medication.

It is important to note that, like all other medications, the recommended dosage of GLP-1 medications is recommended due to it being the safest and most effective amount of medication. Changing your dosage is not recommended unless you have been told to by a healthcare provider. If you feel like your dosage needs to be altered then you should consult with your doctor for further advice. 

Media Coverage

British television show This Morning recently covered the topic of microdosing Mounjaro, speaking with beauty editor Olivia Falcon to understand her experience and providing a medical perspective from Dr. Hussain Al-Zubaidi.

Are there any risks to microdosing GLP-1 injections?

Microdosing GLP-1 injections carries significant risks as it has not been clinically researched or approved. These medications are designed to deliver specific, carefully measured doses, which have undergone testing to ensure their safety and effectiveness. Attempting to microdose can lead to underdosing, reducing the effectiveness of the medication.

Taking a smaller dose does not necessarily reduce the risk of side effects. Even at lower doses, side effects like nausea, vomiting, diarrhoea and gastrointestinal upset are still common. Without proper medical supervision, self-administering microdoses increase the risk of complications [1]. It’s vital to follow the recommended dosage guidelines and consult your healthcare provider if you have concerns about your treatment.

What are the recommended doses for GLP-1 injections?

Mounjaro dosage

The recommended dosage for Mounjaro follows a titration schedule to ensure its effectiveness and minimise side effects. The treatment typically begins with a 2.5mg injection once a week for the first month. After this period, the dose may be increased to 5mg weekly. 

This gradual escalation sees doses rise to 7.5mg, 10mg, 12.5mg, and potentially up to 15mg per week. It’s important to note that not everyone will require higher doses for Mounjaro to be effective and that the decision to alter dosage should be made by a doctor. The titration process allows your healthcare provider to tailor the dosage to your specific needs while reducing the likelihood of side effects [2].

Wegovy dosage

Wegovy is available in five dosage strengths to facilitate a gradual increase during treatment. Typically, treatment begins with a 0.25mg dose once a week for the first four weeks. After this, the dosage is increased every four weeks, until reaching the full dose of 2.4mg per week [3]. This gradual titration helps your body adjust to the medication, reducing the risk of side effects while maximising its effectiveness.

Finals Thoughts

While the concept of microdosing GLP-1 medications like Mounjaro and Wegovy has gained attention, it remains unsupported by clinical evidence and carries significant risks. These medications are designed with carefully researched dosages to ensure safety and efficacy and changing these doses without medical supervision can reduce their effectiveness and increase the likelihood of side effects. If you are considering or currently using GLP-1 medications for weight loss, it is crucial to follow the recommended dosages and consult your healthcare provider about any concerns. 

Sources

[1] Research shows GLP-1 drugs are effective but complex - UChicago Medicine

[2] Mounjaro dosing & titration: Which tirzepatide dosage do I need? - UK Meds

[3] A Simple Guide To Wegovy Dosing & Titration: When & How To Take The Semaglutide Injection For Weight Loss - UK Meds