Mounjaro Blindness: Is Blindness A Side Effect of Tirzepatide?

In this article, we’ll look into whether blindness is a potential side effect of tirzepatide, the active ingredient in Mounjaro. We’ll explore what tirzepatide is prescribed to treat in the UK, whether blindness is mentioned as a side effect on the patient information leaflet and what to do if you experience vision changes while using Mounjaro. If you have any concerns or questions about side effects when using Mounjaro it is important to consult with your doctor.

Key Takeaways

Here are the 5 biggest takeaways from this article about Mounjaro blindness:

• Mounjaro (tirzepatide) is primarily prescribed for managing type 2 diabetes and aiding weight loss.

• Blindness is not mentioned as a side effect of Mounjaro on the patient information leaflet. However, blurred vision, potentially linked to blood sugar changes, may occur, requiring medical attention if severe or sudden.

• Rapid blood sugar improvements associated with Mounjaro can temporarily worsen pre-existing diabetic retinopathy.

• Research suggests a potential link between GLP-1 receptor agonists like Mounjaro and Nonarteritic Anterior Ischemic Optic Neuropathy (NAION), a rare condition causing sudden and possibly permanent vision loss.

• Any vision changes while using Mounjaro should be reported to a doctor immediately.

What is tirzepatide prescribed for in the UK?

In the UK, tirzepatide, sold under the name Mounjaro, is primarily prescribed for aiding weight loss as well as the management of type 2 diabetes [1]. It helps regulate blood sugar levels and supports weight loss, making it particularly effective for people who struggle with both conditions. 

Developed by Eli Lilly and Company, Mounjaro is a weekly self-injectable medication that works best when combined with a healthy, balanced diet and regular exercise. Its dual action of improving glycaemic control and promoting weight loss has made it a popular option for enhancing overall health and well-being.

Can Mounjaro cause blindness?

While Mounjaro (tirzepatide) is not directly associated with causing blindness, some patients may experience blurred vision as a side effect [2]. This is often linked to changes in blood sugar levels, which can temporarily affect eyesight. Severe or sudden vision changes are uncommon, but if they happen, it is crucial to seek medical advice as soon as possible to rule out any serious complications related to diabetes or other underlying conditions.

Diabetic Retinopathy

Diabetic retinopathy is a serious eye condition that affects people with diabetes, caused by damage to the blood vessels in the retina. While blurred vision has not been directly reported as a side effect of Mounjaro, rapid improvements in blood sugar levels associated with this medication can temporarily worsen pre-existing diabetic retinopathy. This is why it is important to discuss any history of diabetic retinopathy with your doctor before starting treatment.

In clinical studies, cases of diabetic retinopathy in people using Mounjaro were rare and occurred in patients with pre-existing conditions. Untreated diabetic retinopathy can lead to severe complications, including blindness. To prevent this, your doctor or ophthalmologist will monitor your eye health closely during treatment.

Nonarteritic anterior ischemic optic neuropathy (NAION)

Research suggests that GLP-1 receptor agonists, including Mounjaro (tirzepatide), may be linked to a rare but serious eye condition called Nonarteritic Anterior Ischemic Optic Neuropathy (NAION). This condition, often described as a “stroke of the optic nerve,” occurs due to reduced blood flow to the optic nerve, which connects the eye to the brain. NAION can lead to sudden vision loss, and in some cases, this loss may be permanent and irreversible [3].

While NAION is the second most common cause of optic nerve damage, it is still rare, affecting an estimated 2.3 to 10.2 people per 100,000 over 50 annually. Recent studies indicate that people with type 2 diabetes using GLP-1 receptor agonists may face an increased risk. If you experience sudden vision changes while taking Mounjaro it is crucial to seek immediate medical attention. Early diagnosis and intervention are vital to managing this condition.

Is blindness listed as a side effect of Mounjaro on the patient information leaflet?

Blindness is not listed as a side effect of Mounjaro (tirzepatide) on the patient information leaflet provided by the manufacturer [4]. However, the leaflet highlights other potential side effects, including nausea and diarrhoea and rare conditions such as severe allergic reactions and inflamed pancreas. Vision-related issues, such as blurred vision, are not mentioned as side effects.

If you experience sudden or significant vision changes while taking Mounjaro, it’s essential to contact your healthcare provider immediately.

What should I do if you experience vision changes when taking Mounjaro?

If you experience vision changes while taking Mounjaro, contact your doctor immediately. These symptoms could highlight an underlying issue such as diabetic retinopathy or Non-arteritic Anterior Ischemic Optic Neuropathy (NAION). 

Your doctor may recommend an eye examination with an ophthalmologist to assess your eye health and determine the cause. It’s also important to review your blood sugar levels, as rapid changes can temporarily affect vision. If you have a history of eye conditions like diabetic retinopathy, make sure your doctor is aware.

Medically Reviewed by:
Dr. Alexis Missick MBChB. MRCGP
GMC Reference no: 7151419
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Sources

[1] A Beginners Guide to Mounjaro for Weight Loss - UK Meds

[2] Tirzepatide: A New Generation Therapeutic for Diabetes Type 2 - PMC.

[3] Mounjaro Eye Side Effects Lawsuit [2024 Update] | King Law

[4] Mounjaro KwikPen 2.5mg solution for injection in pre-filled pen - Patient Information Leaflet (PIL) - (emc).