Scott Weaver
Updated at: March 18, 2025 · 5 min read
What is Alprostadil?
Alprostadil is a medication used to treat erectile dysfunction (ED) by improving blood flow to the penis. It belongs to a class of drugs called prostaglandins and is a synthetic version of prostaglandin E1 (PGE1), a naturally occurring chemical that helps widen blood vessels.
While its primary use is for ED treatment, alprostadil is also sometimes prescribed for other medical conditions related to blood circulation, such as peripheral arterial disease or in newborns with congenital heart defects.
What is Alprostadil?
Alprostadil belongs to a group of medications known as prostaglandins. Prostaglandin E1 is a naturally occurring chemical, and alprostadil is a synthetic form of this. It can be used to help treat a number of different conditions, however, it is primarily used for erectile dysfunction. Erectile dysfunction, often shortened to ED, is a condition that is characterised by the inability to achieve or maintain an erection that is sufficient for sexual intercourse.
Video: Overview of Vitaros
Below is a short explainer video to outline the key features of Vitaros (alprostadil).
How Does Alprostadil Work?
Alprostadil works as a vasodilator, meaning it relaxes and widens blood vessels. When used for ED, it stimulates blood flow into the erectile tissues of the penis, making it easier to achieve and maintain an erection.
Unlike oral ED medications like Viagra (sildenafil) or Cialis (tadalafil), which rely on sexual stimulation to be effective, alprostadil can produce an erection without the need for arousal. This makes it a suitable option for men who have not responded well to other treatments.
How Effective is Alprostadil?
Studies show that 60-80% of men with ED experience improved erections with alprostadil. However, the effectiveness can vary depending on factors such as:
The underlying cause of ED
The form of alprostadil used (cream, injection, or suppository)
The dosage and correct application
The overall health of the patient
Why is Alprostadil Not a First-Line Treatment for ED?
Although alprostadil is effective, oral medications like Viagra and Cialis are usually tried first because they are more convenient and less invasive. Alprostadil is often prescribed when these treatments:
Do not produce the desired results
Cause unwanted side effects
Are not suitable due to medical conditions or medication interactions
Different Forms of Alprostadil
Alprostadil comes in several different forms, each with its own method of application:
1. Alprostadil Cream (Vitaros)
Brand name: Vitaros
How it works: Applied directly to the tip of the penis
Onset: Works within 5-30 minutes
Duration: Lasts up to 2 hours
Key benefit: Non-invasive and easy to apply
2. Alprostadil Injection (Caverject, Edex, Viridal Duo)
How it works: Injected directly into the penis
Onset: Works within 5-15 minutes
Duration: Lasts up to 1 hour
Key benefit: Highly effective and fast-acting, but requires self-injection
3. Alprostadil Urethral Suppository (Muse)
How it works: A small pellet is inserted into the urethra
Onset: Works within 5-10 minutes
Duration: Lasts up to 1 hour
Key benefit: Less invasive than injections, but may cause urethral discomfort
What Are the Side Effects of Alprostadil?
As with any medication, alprostadil can cause side effects. The severity and type of side effects depend on the form of the medication used.
Common Side Effects:
Pain or discomfort in the penis
Mild urethral irritation (when using cream or suppository)
Temporary swelling or redness at the application site
Dizziness or lightheadedness
Serious Side Effects:
Priapism (a prolonged erection lasting more than 4 hours – seek immediate medical help)
Severe pain or bruising at the injection site
Low blood pressure (hypotension)
Allergic reactions (rash, swelling, breathing difficulties)
Can You Buy Alprostadil Online?
Yes, you can buy alprostadil cream (Vitaros) online from UK Meds with a valid prescription. Before purchasing, you will need to complete a free online consultation with a registered independent prescriber to ensure the medication is safe and appropriate for you.
Is Alprostadil Right for You?
Alprostadil may be a good option for men who:
Have not responded well to Viagra, Cialis, or other oral ED medications
Prefer a non-oral treatment for ED
Want fast-acting results
However, it’s important to consult a doctor or pharmacist before using alprostadil to ensure it is safe for you, especially if you have heart conditions, low blood pressure, or take other medications.
Final Thoughts
Alprostadil is an effective treatment for erectile dysfunction, available in different forms such as cream, injection, and urethral suppository. It is often prescribed when other ED treatments fail or are unsuitable. While it can provide quick and reliable erections, it is important to be aware of potential side effects and use it under medical supervision.
If you are considering alprostadil for ED, you can speak to your doctor or complete a free online consultation at UK Meds to find out if this treatment is right for you.
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